Protease-mediated preparation of valganciclovir intermediate

- Synthesis of Valganciclovir intermediate enzymatically has been reported.
- Selective hydrolysis of Cbz protected di-ester of Ganciclovir to produce monoester is carried out.
- Protex-6L, a commercially available and cheap enzyme is used.
- The valganiclovir intermediate prepared is a key intermediate of anti-viral drug, valganciclovir hydrochloride.