Ultrasound irradiation promoted lipase-catalyzed synthesis of flavonoid esters with unsaturated fatty acids

- Ultrasound pretreatment was utilized to promote the enzymatic synthesis of flavonoid esters.
- The esterification time was 24 h shorter than that of stirring process.
- Six flavonoid esters were synthesized with three beneficial unsaturated fatty acids.
- This protocol can potentially be explored for other lipase-catalyzed reactions.