Heterocycles 32. Efficient kinetic resolution of 1-(2-arylthiazol-4-yl)ethanols and their acetates using lipase B from Candida antarctica

- Kinetic resolution of 1-(2-arylthiazol-4-yl)ethanols and their acetates is described.
- Several lipases were screened as biocatalysts.
- CaL-B efficiently catalyzed both acetylation and methanolysis (ee > 90%, E ≫ 200).
- The absolute configuration of the products was determined by the Mosher's method.