کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6531403 | 48836 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enzymatic resolution of methyl (2E, 4R*,5S*)-4-(N-benzyl-N-methyl)amino-5-hydroxyhex-2-enoate
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enzymatic resolution of methyl (2E, 4R*,5S*)-4-(N-benzyl-N-methyl)amino-5-hydroxyhex-2-enoate Enzymatic resolution of methyl (2E, 4R*,5S*)-4-(N-benzyl-N-methyl)amino-5-hydroxyhex-2-enoate](/preview/png/6531403.png)
چکیده انگلیسی
ⶠThe optically active amino-alcohol congener possessing hydroxyl and N,N-disubstituted amino groups with vicinal relationship are important building blocks for the synthesis of biologically and pharmacologically active compounds ⶠLipase-assisted acylation of (±) methyl 4-(N-benzyl-N-methylamino)-5-hydroxy-2(E)-hexenoate using CAL-B with vinyl hexanoate as an acyl donor was carried out to give (4S,5R)-4-(N-benzyl-N-methylamino)-5-hexanoyloxy-2(E)-hexenoate (44%, 99.2% ee) and (4R,5S)-alcohol (46%, 98.2% ee) corresponding to starting material. ⶠThe E-value of the present lipase-assisted resolution was estimated to be more than 1000. ⶠThus obtained methyl (4S,5R)-4-(N-benzyl-N-methylamino)-5-hydroxy-2(E) hexenoate was successfully converted into methyl β-d-vicenisaminide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 69, Issues 1â2, April 2011, Pages 21-26
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 69, Issues 1â2, April 2011, Pages 21-26
نویسندگان
Mikio Fujii, Machiko Ono, Miyuki Sato, Hiroyuki Akita,