کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6553706 | 160896 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Population genetic analysis of insertion-deletion polymorphisms in a Brazilian population using the Investigator DIPplex kit
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
The aim of this study was to estimate the diversity of 30 insertion/deletion (INDEL) markers (Investigator® DIPplex kit) in a sample of 519 individuals from six Brazilian states and to evaluate their applicability in forensic genetics. All INDEL markers were found to be highly polymorphic in the Brazilian population and were in Hardy-Weinberg equilibrium. To determine their forensic suitability in the Brazilian population, the markers were evaluated for discrimination power, match probability and exclusion power. The combined discrimination power (CDP), combined match power (CMP) and combined power of exclusion (CPE) were higher than 0.999999, 3.4Â ÃÂ 10â13 and 0.9973, respectively. Further comparison of 29 worldwide populations revealed significant genetic differences between continental populations and a closer relationship between the Brazilian and European populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International: Genetics - Volume 19, November 2015, Pages 10-14
Journal: Forensic Science International: Genetics - Volume 19, November 2015, Pages 10-14
نویسندگان
Teresinha de Jesus Brabo Ferreira Palha, Elzemar Martins Ribeiro Rodrigues, Giovanna Chaves Cavalcante, Andrea Marrero, IlÃada Rainha de Souza, Clineu Julien Seki Uehara, Carlos Henrique Ares Silveira da Motta, Daniela Koshikene,