Integrated supply chain planning for multinational pharmaceutical enterprises

► We develop simple yet powerful MILP model for multi-period enterprise-wide planning. ► Our model for integrates procurement, production, and distribution constraints. ► The model includes effects of tax differentials, shelf-lives, and waste handling. ► We solve two example problems of planning multinational pharmaceutical enterprise. ► Includes a large problem with 34 entities and 9 products for a period of 5 years.