کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6612086 | 459575 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry
ترجمه فارسی عنوان
اکسیداسیون الکتروشیمیایی فستو ترودین و شناسایی محصولات اکسیداسیون آن با استفاده از کروماتوگرافی مایع و اسپکترومتری جرمی
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کلمات کلیدی
فستو ترودین، اکسیداسیون، هیدرولیز، ولتاژ سنجی، طیف سنجی جرمی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
The electrochemical behavior of fesoterodine (FES), an antimuscarinic drug used for the treatment of urge incontinence and overactive bladder, was investigated using linear sweep and cyclic voltammetry at a stationary and rotating disc glassy carbon electrodes. A single two-electron anodic signal of FES was observed in neutral buffered aqueous methanolic solutions. Kinetics of alkaline hydrolysis of FES to its active metabolite 5-hydroxymethyl tolterodine was investigated by time dependent linear sweep voltammetry. Controlled potential electrolysis of FES solutions was performed at platinum gauze electrode in aqueous-methanolic media. Electrolyzed solutions were analyzed using ultra performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. Two main products of electrochemical oxidation of fesoterodine were identified as 5-formyl fesoterodine (isobutyric acid 2-(3-diisopropylamino-1-phenyl-propyl)-4-formyl-phenyl ester) and N-desisopropylated fesoterodine (isobutyric acid 4-hydroxymethyl-2-(3-isopropylamino-1-phenyl-propyl)-phenyl ester). The mechanism of the electrochemical oxidation of FES has been proposed and confirmed using on-line electrochemistry/mass spectrometry with porous glassy carbon electrode.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 159, 20 March 2015, Pages 131-139
Journal: Electrochimica Acta - Volume 159, 20 March 2015, Pages 131-139
نویسندگان
Pavla KuÄerová, Jana Skopalová, LukáÅ¡ KuÄera, Jan HrbáÄ, Karel Lemr,