کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6614550 | 459626 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultrasensitive and label-free electrochemical DNA biosensor based on water-soluble electroactive dye azophloxine-functionalized graphene nanosheets
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Ultrasensitive and label-free electrochemical DNA biosensor based on water-soluble electroactive dye azophloxine-functionalized graphene nanosheets Ultrasensitive and label-free electrochemical DNA biosensor based on water-soluble electroactive dye azophloxine-functionalized graphene nanosheets](/preview/png/6614550.png)
چکیده انگلیسی
This paper reported an ultrasensitive and label-free electrochemical DNA biosensing platform based on a newly synthesized water-soluble electroactive dye azophloxine-functionalized graphene nanosheets (AP-GNs). Azophloxine can be attached on the graphene surface through synergistic noncovalent charge-transfer and Ï-Ï stacking interactions with graphene. The attachment of azophloxine on the graphene surface not only acts as a stabilizer for graphene but also as the in situ probe for the electrochemical DNA detection. Under optimum conditions, this biosensor exhibited high sensitivity and low detection limit for detecting DNA. The linear range is from 1.0 Ã 10â15 to 1.0 Ã 10â11 mol Lâ1 and the detection limit is 4.0 Ã 10â16 mol Lâ1. Furthermore, this biosensor showed extraordinary capability for single nucleotide polymorphisms (SNPs) assay. The results demonstrate that this AP-GNs based biosensor has potential application in sensitive and selective DNA detection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 113, 15 December 2013, Pages 69-76
Journal: Electrochimica Acta - Volume 113, 15 December 2013, Pages 69-76
نویسندگان
Yanxiu Guo, Yujing Guo, Chuan Dong,