کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6616748 | 459629 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode
ترجمه فارسی عنوان
بررسی گسترده ای از رفتار الکتروشیمیایی بریمونیدین و تعیین آن در الکترودهای کربن شیشه ای
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
The reduction of BRIM occurs as one-step quasi-reversible reaction in acid and neutral medium, reaching the full reversibility in alkaline solutions. Reduction process involves the transfer of two electrons and two protons at the pyrazine ring of quinoxaline moiety, forming a dihydro-derivative. In acid and neutral solutions, brimonidine reduction product is partly oxidized to its hydroxy-derivative. BRIM is also oxidized irreversibly with the transfer of one electron and one proton at secondary amine moiety. The effects of pH of the electrolyte solution, scan rate and BRIM concentration were monitored. The nature of the electrode process was found to be controlled by the adsorption at pH > 6 and the total surface concentration of brimonidine adsorbed onto the GCE surface at pH 7, ÎBRIM = 1.35 Ã 10â10 mol cmâ2 was obtained. Based on this study, differential pulse voltammetric method was developed, validated and suggested for rapid electroanalytical determination of the low concentration of brimonidine. The linearity was achieved within the concentration range from 5 Ã 10â7 to 5 Ã 10â6 M with LOD = 1.6 Ã 10â7 M and LOQ = 5.3 Ã 10â7 M. The method was applied for brimonidine determination in pharmaceutical dosage form, eye drops.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 106, 1 September 2013, Pages 75-81
Journal: Electrochimica Acta - Volume 106, 1 September 2013, Pages 75-81
نویسندگان
Mara M. AleksiÄ, Valentina RaduloviÄ, Danica Agbaba, Vera KapetanoviÄ,