کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6661748 | 1426557 | 2018 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrochemical characterization of a novel nimesulide anti-inflammatory drug analog: LQFM-091
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
Nimesulide is an anti-inflammatory drug (NSAID) whose preferential selectivity for cyclooxygenase-2 (COX-2) leads to fewer adverse effects. Nimesulide acts on a single metabolic pathway of the arachidonic acid cascade. Recent studies show that multi-target NSAID is an important strategy for obtaining drugs fewer adverse effects. LQFM-091 has been proposed as a molecular hybridization from nimesulide and BF-389, with the aim to inhibit two enzymes involved in arachidonic acid metabolic cascade. The aim this work was the electrochemical characterization of LQFM-091. The electrochemical analyzes were conclusive to prove that the electroactive groups are unhindered and were important in this drug action mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 818, 1 June 2018, Pages 92-96
Journal: Journal of Electroanalytical Chemistry - Volume 818, 1 June 2018, Pages 92-96
نویسندگان
Karla Carneiro de Siqueira Leite, Luane Ferreira Garcia, Germán Sanz, Flávio Colmati, Aparecido Ribeiro de Souza, Daniel da Costa Batista, Ricardo Menegatti, Eric de Souza Gil, Rafael Luque,