کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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67113 | 48466 | 2009 | 8 صفحه PDF | دانلود رایگان |

This paper presents the application of zeolite (NaY) supported Pd and Cu catalysts in amination reactions of aryl chlorides. Using 0.1 mol% Pd, good yields could be achieved in the coupling of 4-chloroacetohphenone and piperidine after 6 h at 140 °C. In the second part, we demonstrate two different pathways for transition metal free amination of activated aryl chlorides and fluorides, and, respectively, non- and deactivated aryl chlorides. These reactions were performed with excellent yields in short reaction time without any transition metal catalyst under optimized reaction conditions. Activated aryl halides react smoothly using 2.1 equiv. amine without additional base whereas deactivated aryl halides require the use of a strong base (KOtBu) for high conversion. DFT calculations were performed to study the surprising influence of substitutents at the aromatic ring on selectivity in metal free aminations found in this work.
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Journal: Journal of Molecular Catalysis A: Chemical - Volume 303, Issues 1–2, 15 April 2009, Pages 15–22