Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using Ziegler–Natta catalyst system under solvent free conditions

A Ziegler–Natta catalyst system (TiCl4-MgCl2/magnesium chloride-methanol adduct) was efficiently found to catalyze the three component Biginelli reaction of an aldehyde, β-keto ester, and urea or thiourea under solvent free conditions to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones in excellent yields. The enhanced surface areas of TiCl4-MgCl2-methanol adduct plays significant role in providing an efficient synthesis of Biginelli compounds.

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