کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6787925 | 1432591 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein E4 genotype
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کلمات کلیدی
PPARγPBLICD-10RTPCRcycle threshold - آستانه چرخهapolipoprotein E4 - آپولیپوپروتئین E4Alzheimer's disease - بیماری آلزایمرTelomere - تلومرDiabetes mellitus type 2 - دیابت نوع 2Peripheral blood leukocyte - لکوسیت خون محیطیReal time polymerase chain reaction - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیperoxisome proliferator activated receptors - گیرنده های فعال proliferator فعال است
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein E4 genotype Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein E4 genotype](/preview/png/6787925.png)
چکیده انگلیسی
Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. Both dementia and diabetes mellitus type 2 are independently associated with telomere shortening. We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n = 70) and cognitively normal control groups (n = 55) with and without comorbid diabetes mellitus type 2. Relative telomere length was highest in the control group (Q2 = 0.91) followed by dementia (Q2 = 0.48) and dementia with comorbid diabetes mellitus type 2 (Q2 = 0.39). Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P > 0.05). The findings suggest that relative telomere length is unrelated to apolipoprotein E4 genotype in dementia and cognitive normal subjects with or without comorbid diabetes mellitus type 2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Psychiatry - Volume 12, December 2014, Pages 58-62
Journal: Asian Journal of Psychiatry - Volume 12, December 2014, Pages 58-62
نویسندگان
Lakshmi Narayanan Kota, Srikala Bharath, Meera Purushottam, Pradip Paul, Palanimuthu Thangaraju Sivakumar, Mathew Varghese, Sanjeev Jain,