کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6794179 | 1432743 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The timing and duration of estradiol treatment in a rat model of the perimenopause: Influences on social behavior and the neuromolecular phenotype
ترجمه فارسی عنوان
زمان و مدت درمان استرادیول در یک مدل موش از پرهننسپوز: تأثیرات بر رفتار اجتماعی و فنوتیپ نورومولکولیک
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کلمات کلیدی
اتراستیل، آوالیزاسیون التراسونیک، یائسگی، هیپوتالاموس، رفتار اجتماعی، بیان ژن، اکسی توسین، وازوپرسین، دوپامین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
This study tested the effects of timing and duration of estradiol (E2) treatment, factors that are clinically relevant to hormone replacement in perimenopausal women, on social behavior and expression of genes in brain regions that regulate these behaviors. Female rats were ovariectomized (OVX) at 1Â year of age, roughly equivalent to middle-age in women, and given E2 or vehicle for different durations (3 or 6Â months) and timing (immediately or after a 3-month delay) relative to OVX. Social and ultrasonic vocalization (USV) behaviors were assessed at the 3 and 6Â month timepoints, and the rats' brains were then used for gene expression profiling in hypothalamus (supraoptic nucleus, paraventricular nucleus), bed nucleus of the stria terminalis, medial amygdala, and prefrontal cortex using a 48-gene qPCR platform. At the 3-month post-OVX testing period, E2 treatment significantly decreased the number of frequency-modulated USVs emitted. No effects of hormone were found at the 6-month testing period. There were few effects of timing and duration of E2 in a test of social preference of a rat given a choice between her same-sex cagemate and a novel conspecific. For gene expression, effects of timing and duration of E2 were region-specific, with the majority of changes found for genes involved in regulating social behavior such as neuropeptides (Oxt, Oxtr & Avp), neurotransmitters (Drd1, Drd2, Htr2a, Grin2d & Gabbr1), and steroid hormone receptors (Esr2, Ar, Pgr). These data suggest that the mode of E2 treatment has specific effects on social behavior and expression of target genes involved in the regulation of these behaviors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 97, January 2018, Pages 75-84
Journal: Hormones and Behavior - Volume 97, January 2018, Pages 75-84
نویسندگان
Alexandra N. Garcia, Christina Depena, Kelsey Bezner, Weiling Yin, Andrea C. Gore,