کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6811806 | 1433785 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of the efficacy of omega-3 fatty acids on metabolic and inflammatory parameters in patients with schizophrenia taking clozapine and sodium valproate
ترجمه فارسی عنوان
ارزیابی اثربخشی اسید چرب امگا -3 بر پارامترهای متابولیک و التهابی در بیماران مبتلا به اسکیزوفرنیا با مصرف کلوزاپین و والپروات سدیم
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کلمات کلیدی
جنون جوانی، کلوزاپین، امگا 3،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Omega-3 fatty acid (FA) supplementation has been reported to improve several cardio-metabolic risk factors. We aimed to assess the efficacy of omega-3 fatty acids on metabolic and inflammatory indices in patients with schizophrenia who were taking clozapine and sodium valproate. All patients were on a stable dose of 300-400Â mg of clozapine for 3 months. Subjects were randomized to treatment with either omega-3 fatty acid (4Â gr/day) or a placebo for 8 weeks. Height, weight, abdominal circumference, serum lipid profile, fasting blood glucose (FBG), and serum high sensitivity-C-reactive protein (hs-CRP) were determined at baseline and after 8 weeks of treatment. Fifty six subjects were recruited into the study. Patients with schizophrenia who were in the group receiving omega-3 FA capsules had an improvement in some anthropometric indices including weight, BMI, wrist and waist circumference, compared to the placebo group. Only changes in waist circumferences remained significantly different after adjustment for serum fasted TG. Our results showed omega-3 FA supplementation can improve some anthropometric indices in patients with schizophrenia who are taking clozapine pharmacotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 261, March 2018, Pages 243-247
Journal: Psychiatry Research - Volume 261, March 2018, Pages 243-247
نویسندگان
Fatemeh Behdani, Seyede Narjes Roudbaraki, Maryam Saberi-Karimian, Maryam Tayefi, Paria Hebrani, Amir Akhavanrezayat, Sadegh Vahabi Amlashi, Gordon A. Ferns, Majid Ghayour-Mobarhan,