کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6813274 | 545466 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression](/preview/png/6813274.png)
چکیده انگلیسی
Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 242, 30 August 2016, Pages 277-280
Journal: Psychiatry Research - Volume 242, 30 August 2016, Pages 277-280
نویسندگان
Lyubov Bryushkova, Clement Zai, Sheng Chen, Irene Pappa, Viara Mileva, Henning Tiemeier, Marian Bakermans-Kranenburg, James L. Kennedy, Joseph H. Beitchman,