کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6814000 | 545869 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes
ترجمه فارسی عنوان
لایه الیاف شبکیه و ضخامت ماکولا در بیماران مبتلا به اسکیزوفرنی: تأثیرات بیماری های اخیر
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Optical coherence tomography (OCT) has been recently used to investigate neuropsychiatric disorders. We aimed to study retinal OCT measures of patients with schizophrenia with respect to healthy controls, and to evaluate possible differences between recent illness episode (RIE) and non-recent illness episode (NRIE) patients. Thirty schizophrenia patients were classified as RIE (n=10) or NRIE (n=20), and compared with 30 matched controls. Statistical analyses included linear mixed-effects models to study the association between OCT measures and group membership. Multivariate models were used to control for potential confounders. In the adjusted linear mixed-effects regression model, patients had a significantly thinner retinal nerve fiber layer (RNFL) in overall measurements, and in the nasal, superior and inferior quadrants. Macular inner ring thickness and macular volume were also significantly smaller in patients than controls. Compared with controls, in the adjusted model only NRIE (but not RIE) patients had significantly reduced RNFL overall measures, superior RNFL, nasal RNFL, macular volume, and macular inner ring thickness. No significant correlation was found between illness duration and retinal measurements after controlling for age. In conclusion, retinal parameters observed using OCT in schizophrenia patients could be related to clinical status and merit attention as potential state biomarkers of the disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 229, Issues 1â2, 30 September 2015, Pages 230-236
Journal: Psychiatry Research - Volume 229, Issues 1â2, 30 September 2015, Pages 230-236
نویسندگان
Francisco J. Ascaso, Roberto Rodriguez-Jimenez, Laura Cabezón, Raúl López-Antón, Javier Santabárbara, Concepción De la Cámara, Pedro J. Modrego, Miguel A. Quintanilla, Alexandra Bagney, Leticia Gutierrez, Nancy Cruz, José A. Cristóbal,