کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6818313 | 547073 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chlorella vulgaris reduces the impact of stress on hypothalamic-pituitary-adrenal axis and brain c-fos expression
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کلمات کلیدی
MEAACTHLSVHeteronuclear RNAALACRFhnRNAMPFCRIAmedial amygdala - آمدیگدال medialα-linolenic acid - اسید α-لینولنیکLinoleic acid - اسید لینولئیکradioimmunoassay - رادیوایمونواسیDorsal raphé - رفسنجی پشتیForced swimming - شنا کردن اجباریcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینlocus coeruleus - لوکوس سیرولئوسPVN - مالیات بر ارزش افزودهHypothalamic-pituitary-adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالHPA axis - محور هیپوتالاموس-هیپوفیز-آدرنالHypothalamic paraventricular nucleus - هسته پروبیالیک هیپوتالامیکadrenocorticotropic hormone - هورمون adrenocorticotropicChlorella vulgaris - کلرلا ولگاریسCorticosterone - کورتیکوسترونGlucose - گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Predominantly emotional stressors activate a wide range of brain areas, as revealed by the expression of immediate early genes, such as c-fos. Chlorella vulgaris (CV) is considered a biological response modifier, as demonstrated by its protective activities against infections, tumors and stress. We evaluated the effect of acute pretreatment with CV on the peripheral and central responses to forced swimming stress in adult male rats. Pretreatment with CV produced a significant reduction of stress-related hypothalamic-pituitary-adrenal activation, demonstrated by decreased corticotrophin releasing factor gene expression in the hypothalamic paraventricular nucleus (PVN) and lower ACTH response. Hyperglycemia induced by the stressor was similarly reduced. This attenuated neuroendocrine response to stress occurred in parallel with a diminished c-fos expression in most evaluated areas, including the PVN. The data presented in this study reinforce the usefulness of CV to diminish the impact of stressors, by reducing the HPA response. Although our results suggest a central effect of CV, further studies are necessary to understand the precise mechanisms underpinning this effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 65, March 2016, Pages 1-8
Journal: Psychoneuroendocrinology - Volume 65, March 2016, Pages 1-8
نویسندگان
Julia Souza Queiroz, Ignacio MarÃn Blasco, Humberto Gagliano, Nuria Daviu, Almudena Gómez Román, Xavier Belda, Javier Carrasco, Michelle C. Rocha, João Palermo Neto, Antonio Armario,