کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6824658 | 548502 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia
ترجمه فارسی عنوان
ارتباط بین ژنوتیپ های گیرنده اکسی توسین و عملکرد شناختی اجتماعی در افراد مبتلا به اسکیزوفرنیا
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Individuals with schizophrenia often show substantial deficits in social cognitive abilities, which are strongly associated with social functioning. To advance our understanding of the genetic variation that is associated with social cognitive deficits in schizophrenia, we genotyped 74 schizophrenia outpatients who completed social cognitive performance measures assessing mentalizing, social perception, and emotional intelligence, as well as clinical symptoms. We assessed seven single nucleotide polymorphisms (SNPs) of the oxytocin receptor (OXTR) previously found to show replicable associations with socio-emotional processes. For one of the seven SNPs, rs2268493, the 'T' allele was significantly associated with poorer performance on a composite social cognition index, as well as specific tests of mentalizing and social perception. None of the SNPs were associated with clinical symptoms. Though the sample size is small, these findings provide initial support for the involvement of genetic variants of the OXTR in social cognitive impairments in schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 159, Issues 2â3, November 2014, Pages 353-357
Journal: Schizophrenia Research - Volume 159, Issues 2â3, November 2014, Pages 353-357
نویسندگان
Michael C. Davis, William P. Horan, Erika L. Nurmi, Shemra Rizzo, Wendy Li, Catherine A. Sugar, Michael F. Green,