کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6825715 | 548104 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postmortem analysis of cardiovascular deaths in schizophrenia: A 10-year review
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Schizophrenia is a devastating mental disorder, associated with mortality rates up to three times higher than those in the general population. This post-mortem study sought to investigate the causes of death in a consecutive series of schizophrenia cases, with a specific focus on cardiovascular disease and sudden death. A 10-year review of autopsies in schizophrenia related-cases performed at the Department of Forensic Medicine in Sydney, Australia was undertaken. Premorbid clinical and demographic information was recorded, as well as the key pathological findings and final cause of death. From 2003 to 2012, there were 19,478 postmortem examinations performed of which 683 (3.5%) were deaths in people with a history of schizophrenia. In these cases, the mean age at death was 51 years (range 18-93 years), with 43% in the 41-60 year age group. Males comprised 67% of cases. Overall, 62% of cases had a BMI â¥Â 25 kg/m2, indicating overweight or obese individuals. The three primary causes of death were “cardiovascular” (23%), “suicide” (20%), and “drug toxicity” (17%). In 11% of cases (n = 72), no definitive cause of death was found, the so-called “unexplained” cases. In conclusion, patients with schizophrenia have premature mortality. The major contributing factors include cardiovascular diseases, suicide and drug toxicity. The “unexplained” and frequently sudden deaths may suggest underlying cardiac arrhythmias as a cause of death in a subgroup of schizophrenia patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 150, Issues 2â3, November 2013, Pages 398-403
Journal: Schizophrenia Research - Volume 150, Issues 2â3, November 2013, Pages 398-403
نویسندگان
Joanna Sweeting, Johan Duflou, Christopher Semsarian,