کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6826168 | 548481 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered volume and lateralization of language-related regions in first-episode schizophrenia
ترجمه فارسی عنوان
حجم تغییر یافته و لاترالیزه کردن مناطق مرتبط با زبان در ابتدای اسکیزوفرنیا
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کلمات کلیدی
اسکیزوفرنی اول قسمت، تغییر ماده خاکستری عدم تقارن مغزی، نوروپاتولوژی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-episode schizophrenia (FESZ), and their correlations with clinical measures. Magnetic resonance imaging scans were obtained from a total of 89 participants. Thirty-three FESZ patients and 41 matched healthy controls were included in the analysis. Compared to healthy controls, the FESZ patients showed decreased gray matter volume (GMV) in the frontal cortex, anterior cingulate cortex, temporal cortex, parahippocampal, fusiform, insula, and lingual; and increased GMV in cerebellum. Both male and female patients displayed an increased rightward lateralization in frontal and temporal cortex, which was significantly correlated with the severity of symptoms and social functioning. These findings may provide the neurological substrate for the etiology and clinical manifestations of the illness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 148, Issues 1â3, August 2013, Pages 168-174
Journal: Schizophrenia Research - Volume 148, Issues 1â3, August 2013, Pages 168-174
نویسندگان
Jianhua Sheng, Yikang Zhu, Zheng Lu, Na Liu, Nan Huang, Zhongwei Zhang, Ling Tan, Chunbo Li, Xin Yu,