کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6826862 | 548523 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Default mode network activity in schizophrenia studied at resting state using probabilistic ICA
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Amygdala - آمیگدال، بادامهSchizophrenia - اسکیزوفرنی یا شیزوفرنیFunctional magnetic resonance imaging (fMRI) - افامآرآی، تصویرسازی تشدید مغناطیسی کارکردی Independent component analysis (ICA) - تجزیه و تحلیل جزء مستقل (ICA)Resting state - حالت استراحتDefault mode network (DMN) - شبکه حالت پیش فرض (DMN)prefrontal cortex (PFC) - قشر prefrontal (PFC)
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alterations in brain function in schizophrenia and other neuropsychiatric disorders are evident not only during specific cognitive challenges, but also from functional MRI data obtained during a resting state. Here we apply probabilistic independent component analysis (pICA) to resting state fMRI series in 25 schizophrenia patients and 25 matched healthy controls. We use an automated algorithm to extract the ICA component representing the default mode network (DMN) as defined by a DMN-specific set of 14 brain regions, resulting in z-scores for each voxel of the (whole-brain) statistical map. While goodness of fit was found to be similar between the groups, the region of interest (ROI) as well as voxel-wise analysis of the DMN showed significant differences between groups. Healthy controls revealed stronger effects of pICA-derived connectivity measures in right and left dorsolateral prefrontal cortices, bilateral medial frontal cortex, left precuneus and left posterior lateral parietal cortex, while stronger effects in schizophrenia patients were found in the right amygdala, left orbitofrontal cortex, right anterior cingulate and bilateral inferior temporal cortices. In patients, we also found an inverse correlation of negative symptoms with right anterior prefrontal cortex activity at rest and negative symptoms. These findings suggest that aberrant default mode network connectivity contributes to regional functional pathology in schizophrenia and bears significance for core symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 138, Issues 2â3, July 2012, Pages 143-149
Journal: Schizophrenia Research - Volume 138, Issues 2â3, July 2012, Pages 143-149
نویسندگان
Gianluca Mingoia, Gerd Wagner, Kerstin Langbein, Raka Maitra, Stefan Smesny, Maren Dietzek, Hartmut P. Burmeister, Jürgen R. Reichenbach, Ralf G.M. Schlösser, Christian Gaser, Heinrich Sauer, Igor Nenadic,