کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6827009 | 548143 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study](/preview/png/6827009.png)
چکیده انگلیسی
In patients, after controlling for possible confounding variables, lower baseline GSH levels were significantly associated with greater volume decrease in left frontal (B = 0.034, 95% confidence interval (CI): 0.011 to 0.056, r = 0.620, p = 0.006), parietal (B = 0.039, 95% CI: 0.020 to 0.059, r = 0.739, p = 0.001), temporal (B = 0.026, 95% CI: 0.016 to 0.036, r = 0.779, p < 0.001), and total (B = 0.022, 95% CI: 0.014 to 0.031, r = 0.803, p < 0.001) gray matter, and with greater increase in total CSF (B = â 0.560, 95% CI: â 0.270 to â 0.850, r = â 0.722, p = 0.001). Controls did not show significant associations between brain volume changes and GSH levels. GSH deficit during the first psychotic episode was related to greater loss of cortical GM two years later in patients with first-episode EOP, suggesting that oxidative damage may contribute to the progressive loss of cortical GM found in patients with first-episode psychosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 137, Issues 1â3, May 2012, Pages 58-65
Journal: Schizophrenia Research - Volume 137, Issues 1â3, May 2012, Pages 58-65
نویسندگان
David Fraguas, Ana Gonzalez-Pinto, Juan Antonio Micó, Santiago Reig, Mara Parellada, Mónica MartÃnez-Cengotitabengoa, Josefina Castro-Fornieles, Marta Rapado-Castro, Immaculada Baeza, Joost Janssen, Manuel Desco, Juan Carlos Leza, Celso Arango,