Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls

The present study replicates earlier findings showing an association between the functional Val158Met polymorphism and working memory performance, with schizophrenia subjects particularly vulnerable. Furthermore, our findings suggest that other parts of the COMT gene seem to affect several related cognitive domains, which further support the notion that COMT is a modifier gene in prefrontal dopamine functioning.