کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6828312 547960 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: A meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: A meta-analysis
چکیده انگلیسی
The results of research on the relation of family history (FH) of psychosis with clinical presentation in schizophrenia have been mixed. To date, there have been no comprehensive reviews that have examined this body of research. The current review quantitatively evaluates research on the relation of FH with two aspects of schizophrenia, age-at-onset and symptom presentation. Studies investigating the influence of a FH on age-at-onset (N = 15 studies), age-at-onset and sex (N = 12 studies), and/or positive (N = 11 studies) and negative symptoms (N = 12 studies) in patients with schizophrenia were included in the meta-analyses. Results showed that FH has a small but significant impact on age-at-onset as well as negative symptoms. Of most interest was the finding that sex differences in age-at-onset are not observed in samples with a FH. Furthermore, there was a significant interaction between FH and sex with respect to negative symptoms. The findings of the current review are discussed in light of the diathesis-stress model. Theoretical assumptions and empirical research are reviewed to support the notion that FH influences susceptibility and presentation through similar mechanisms. Implications of the current findings, limitations of the review, and directions for future research are highlighted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 120, Issues 1–3, July 2010, Pages 121-130
نویسندگان
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