کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6828797 548569 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats
چکیده انگلیسی
Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid). Using SDS-PAGE and western blotting technique, we observed that CX43 protein expression in prefrontal cortex was significantly increased following chronic treatment with fluoxetine and clozapine, while it was significantly decreased by haloperidol and lithium. GFAP protein expression was significantly decreased following chronic treatment with clozapine and valproic acid. These results suggest that astroglial markers GFAP and CX43 could be potential targets for therapeutic intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 104, Issues 1–3, September 2008, Pages 127-134
نویسندگان
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