کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6828846 | 548569 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia](/preview/png/6828846.png)
چکیده انگلیسی
Prior work found the APOL1, 2 and 4 genes, located on chromosome 22q12.3-q13.1, to be upregulated in brains of schizophrenic patients. We performed a family-based association study using 130 SNPs tagging the APOL gene family (APOL1-6). The subjects were 112 African-American (AA), 114 European-American (EA), 109 Chinese (Ch) and 42 Japanese (Jp) families with schizophrenia (377 families, 1161 genotyped members and 647 genotyped affected in total). Seven SNPs had p-values < 0.05 in the APOL1, 2 and 4 regions for the AA, EA and combined (AA and EA) samples. In the AA sample, two SNPs, rs9610449 and rs6000200 showed low p-values; and a haplotype which comprised these two SNPs yielded a p-value of 0.00029 using the global test (GT) and the allele specific test (AST). The two SNPs and the haplotype were associated with risk for schizophrenia in African-Americans. In the combined (AA and EA) sample, two SNPs, rs2003813 and rs2157249 showed low p-values; and a three SNP haplotype including these two SNPs was significant using the GT (p = 0.0013) and the AST (p = 0.000090). The association of this haplotype with schizophrenia was significant for the entire (AA, EA, Ch and Jp) sample using the GT (p = 0.00054) and the AST (p = 0.00011). Although our study is not definitive, it suggests that the APOL genes should be more extensively studied in schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 104, Issues 1â3, September 2008, Pages 153-164
Journal: Schizophrenia Research - Volume 104, Issues 1â3, September 2008, Pages 153-164
نویسندگان
Sakae Takahashi, Yu-hu Cui, Yong-hua Han, Jesen A. Fagerness, Brian Galloway, Yu-cun Shen, Takuya Kojima, Makoto Uchiyama, Stephen V. Faraone, Ming T. Tsuang,