کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6829585 | 547990 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A single 20Â mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia
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کلمات کلیدی
PFCSPMDLPFCAFNISchizophrenia - اسکیزوفرنی یا شیزوفرنیMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیDopamine - دوپامینprefrontal cortex - قشر prefrontaldorsolateral prefrontal cortex - قشر پیشانی غدد درون رحمیperf - پرفیومPerfusion - پرفیوژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dopamine D1 receptors play an important role in memory and cognition in non-human primates. Dopamine D1 agonists have been shown to reverse performance deficits in both aged non-human primates and in primates with lesions to dopamine systems. This study explored whether a single dose of the first full D1 agonist dihydrexidine (DAR-0100) would cause changes in brain activity (perfusion) in dopamine-rich brain regions. We used a new gadolinium-contrast magnetic resonance perfusion scanning technique to measure brain activity. A within-subject cross-over double-blind randomized design was used in 20 adults with SCID-diagnosed schizophrenia. Each morning at 0800Â h, they were scanned on a 3.0 T MRI scanner for perfusion. They then received either 20Â mg of dihydrexidine, or placebo, subcutaneously over 15Â min. Over the next 45Â min, they had intermittent MRI scans. Two days later, they had a repeat of the Day 1 schedule, but received the opposite treatment from that given on the first day. Within-day, as well as between-day, comparisons were made to test for perfusion effects of dihydrexidine. Analysis revealed that dihydrexidine induced a significant increase in both prefrontal and non-prefrontal perfusion compared to placebo. The greatest increases occurred approximately 20Â min after dihydrexidine infusion, consistent with the short pharmacokinetic half-life of dihydrexidine. These data are consistent with the hypothesis formulated from studies of non-human primates that dihydrexidine and other D1 agonists may be able to modulate prefrontal dopaminergic function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 94, Issues 1â3, August 2007, Pages 332-341
Journal: Schizophrenia Research - Volume 94, Issues 1â3, August 2007, Pages 332-341
نویسندگان
Qiwen Mu, Kevin Johnson, Paul S. Morgan, Emily L. Grenesko, Christine E. Molnar, Berry Anderson, Ziad Nahas, F. Andrew Kozel, Samet Kose, Michael Knable, Prabhavathi Fernandes, David E. Nichols, Richard B. Mailman, Mark S. George,