کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
68699 48520 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tailoring the ligand structure to the reagent in the mandelamide-Ti(IV) catalyzed enantioselective addition of dimethyl- and diethylzinc to aldehydes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Tailoring the ligand structure to the reagent in the mandelamide-Ti(IV) catalyzed enantioselective addition of dimethyl- and diethylzinc to aldehydes
چکیده انگلیسی

Amides derived from (S)-(+)-mandelic acid in the presence of titanium isopropoxide catalyze the enantioselective addition of dimethyl- and diethylzinc to aldehydes with good yields and ee up to 90%. Because of the modular character of the mandelamides, the structure of the ligand can be tailored to obtain the best results with each reagent. Thus, best results with dimethylzinc are obtained with N-benzyl mandelamide while N-(pyridin-2-yl) mandelamide is the best ligand for the addition of diethylzinc.

Tailoring the ligand structure to the reagent in the mandelamide-Ti(IV) catalyzed enantioselective addition of dimethyl- and diethylzinc to aldehydes Mandelamides in the presence of titanium isopropoxide catalyze the enantioselective addition of dimethyl- and diethylzinc to aldehydes. Highest enantioselectivity requires tailoring the mandelamide ligand for each reagent.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis A: Chemical - Volume 276, Issues 1–2, 17 October 2007, Pages 235–243
نویسندگان
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