کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
68699 | 48520 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Tailoring the ligand structure to the reagent in the mandelamide-Ti(IV) catalyzed enantioselective addition of dimethyl- and diethylzinc to aldehydes Tailoring the ligand structure to the reagent in the mandelamide-Ti(IV) catalyzed enantioselective addition of dimethyl- and diethylzinc to aldehydes](/preview/png/68699.png)
Amides derived from (S)-(+)-mandelic acid in the presence of titanium isopropoxide catalyze the enantioselective addition of dimethyl- and diethylzinc to aldehydes with good yields and ee up to 90%. Because of the modular character of the mandelamides, the structure of the ligand can be tailored to obtain the best results with each reagent. Thus, best results with dimethylzinc are obtained with N-benzyl mandelamide while N-(pyridin-2-yl) mandelamide is the best ligand for the addition of diethylzinc.
Tailoring the ligand structure to the reagent in the mandelamide-Ti(IV) catalyzed enantioselective addition of dimethyl- and diethylzinc to aldehydes Mandelamides in the presence of titanium isopropoxide catalyze the enantioselective addition of dimethyl- and diethylzinc to aldehydes. Highest enantioselectivity requires tailoring the mandelamide ligand for each reagent.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 276, Issues 1–2, 17 October 2007, Pages 235–243