Microbial transformation of prenylflavonoids from Psoralea corylifolia by using Cunninghamella blakesleeana and C. elegans

• Biotransformations of three prenylflavonoids have been investigated.
• Total seven biotransformation products including six new ones were identified.
• Their agonistic activities for PPAR γ were assayed.

Cunninghamella blakesleeana AS 3.0970 and AS 3.0910 and C. elegans AS 3.2028 were first used for biotransforming three major prenylflavonoids from Psoralea corylifolia, namely bavachinin, bavachin, and isobavachalcone. A total of seven biotransformation products, including six new compounds, were obtained and identified. The agonistic activities of peroxisome proliferator-activated receptor-γ against substrates and biotransformation products were also evaluated.

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