Drug delivery investigations of quaternised poly(propylene imine) dendrimer using nimesulide as a model drug

- Quaternised poly(propylene imine) dendrimer of generation-3, QPPI (G3), is expected to serve as drug carrier for poorly soluble drugs like nimesulide, NMD.
- QPPI (G3) forms complex with NMD which reflects in significant drug loading potential.
- This complexation leads to increase the solubility and sustains the release of NMD under in vitro conditions.
- QPPI (G3) has reduced the cytotoxicity in comparison with PPI (G3) dendrimer.
- QPPI (G3) is a promising candidate in the design of polymeric drug delivery systems to enhance the bioavailability of the poorly soluble drugs.