کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
69848 48796 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aspergillus genus as a source of new catalysts for sulfide oxidation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Aspergillus genus as a source of new catalysts for sulfide oxidation
چکیده انگلیسی

This work extends the present knowledge about the ability of filamentous fungi to selectively transform sulfur-containing compounds. Here, it has been demonstrated that several species of the Aspergillus genus are able to perform chemo- and stereoselective oxidation of organic sulfides. Two substrates were chosen as models, the aliphatic cyclohexyl(methyl)sulfide and the alkyl aryl sulfide, thioanisole. All the tested strains showed the ability to oxidize cyclohexyl(methyl)sulfide, whereas most of them oxidized thioanisole. In all cases R-stereoselectivity was observed and full chemoselectivity was verified since no sulfone was detected. Several biotransformation parameters such as the employment of growing or resting cell, different head-space volumes, age of the cultures, bio-reaction times and biocatalyst/substrate ratios resulted crucial in the optimization of the processes. Thus, when using isopropyl alcohol as co-solvent in growing cell systems, chemo- and stereoselectivity could be modulated. Among the studied strains, Aspergillus japonicus ICFC 744/11 was found to be a promising whole cell biocatalyst to prepare enantioenriched sulfoxides since after optimization, either conversion and optical purity of (R)-cyclohexyl(methyl)sulfoxide were excellent (c: 100%, ee > 99%).

Figure optionsDownload as PowerPoint slideHighlights
► Aspergilli are described for stereoselective oxidation of prochiral sulfides.
► (R)-stereoselectivity and full chemoselectivity were achieved.
► Biotransformation parameters were optimized.
► A. japonicus is an excellent biocatalyst to prepare enantioenriched sulfoxides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 82, October 2012, Pages 32–36
نویسندگان
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