Biotransformation of spirolaxine by Absidia cuneospora and Trametes hirsuta: Formation of β-glycosyl and β-xylosyl derivatives

► (+)-Spirolaxine represent a bioactive metabolite produced by cultures of the white rot fungus Sporotrichum laxum (Basidiomycetae). ► Incubation of spirolaxine with the fungus Absidia cuneospora afforded the 5β-glucosyl derivative with the 32% yield and demonstrated a good antiangiogenic activity. ► Trametes hirsuta transform the same metabolite into 5β-xylosyl derivative with a 70% yield.