کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
70010 | 48805 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enantioselective preparation of (R) and (S)-3-hydroxycyclopentanone by kinetic resolution
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enantioselective preparation of (R) and (S)-3-hydroxycyclopentanone by kinetic resolution Enantioselective preparation of (R) and (S)-3-hydroxycyclopentanone by kinetic resolution](/preview/png/70010.png)
چکیده انگلیسی
A straightforward approach to enantiomerically enriched (R) and (S)-3-hydroxycyclopentanone is described. The key step involves a kinetic resolution of racemic 3-hydroxycyclopentanone using commercial Pseudomonas cepacia lipase immobilized on diatomite (Amano lipase PS-DI). The absolute stereochemistry of the product was determined by derivatization into (R)-3-(benzyloxy)cyclopentanone.
Figure optionsDownload as PowerPoint slideHighlights
► Efficient preparation of optically pure 3-hydroxycyclopentanone.
► Kinetic resolution by lipase catalyzed acylation with vinyl acetate.
► Kazlauskas’ rule ambiguous with small cyclic substrates.
► Absolute stereochemistry confirmed by derivatization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volumes 85–86, January 2013, Pages 239–242
Journal: Journal of Molecular Catalysis B: Enzymatic - Volumes 85–86, January 2013, Pages 239–242
نویسندگان
Bi-Shuang Chen, Ulf Hanefeld,