کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
70024 48806 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Baeyer–Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Baeyer–Villiger oxidation with peracid generated in situ by CaLB-CLEA catalyzed perhydrolysis
چکیده انگلیسی

Candida antarctica lipase B, immobilized as cross linked enzyme aggregates (CLEAs) was used to mediate the Baeyer–Villiger oxidation of cyclohexanone to ɛ-caprolactone, and the reaction was compared with the one using Novozym® 435 as catalyst. The conversion was dependent on the initial concentration of cyclohexanone, and was about 90% after 48 h at concentrations of up to 0.25 M but was decreased at higher concentrations. Caprolactone concentrations up to 0.6 M had no effect on the reaction efficiency. Among the cyclic ketones tested, the highest degree of conversion was achieved for cyclopentanone (88%) and the lowest for cyclooctanone (about 2%). The effect of methyl substitution and position of substitution on the cycloketone was studied using methylcyclohexanone and it has shown to influence the conversion efficiency. Both hydrogen peroxide and the reaction by-product acetic acid had a deleterious effect on the stability of the biocatalyst.

Figure optionsDownload as PowerPoint slideHighlights
► In situ generation of peracids by CaLB-CLEA.
► Peracids use for the Baeyer–Villiger oxidation of cyclohexanone.
► Caprolactone production in 2 days reaching a maximum of 70%.
► Hydrogen peroxide and acetic acid were the main factors for enzyme lost activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 89, May 2013, Pages 67–72
نویسندگان
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