کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
70532 | 48837 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of triglycerides of phenylbutyric acids by lipase-catalyzed glycerolysis in a solvent-free system
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
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چکیده انگلیسی
Triphenylbutyrin, a triglyceride prodrug of 4-phenylbutyric acid, has potential for use in drug delivery systems. Immobilized Candida antarctica lipase B catalyzed the synthesis of triphenylbutyrin by glycerolysis of 4-phenylbutyrate with glycerol in a solvent-free system. The use of 4-phenylbutyate with a leaving alcohol moiety in the acyl-transfer reaction can shift the equilibrium of the reaction toward the synthesis of triphenylbutyrin, since the alcohol by-product can be removed by vacuum. A 97% yield of triphenylbutyrin was achieved in a solvent-free system at a reaction temperature of 75 °C by combination of molecular sieves to limit the hydrolysis side reaction and a vacuum system to shift the reaction equilibrium in a solvent-free system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 61, Issues 3â4, December 2009, Pages 117-122
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 61, Issues 3â4, December 2009, Pages 117-122
نویسندگان
Chun-Sheng Chang, Pei-Lin Wu,