کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
70648 48839 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A short-step chemo-enzymatic synthesis of a precursor for l-nucleosides from d-lyxose
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
A short-step chemo-enzymatic synthesis of a precursor for l-nucleosides from d-lyxose
چکیده انگلیسی

A new chemo-enzymatic route to tetra-O-acetyl-l-ribofuranose from d-lyxose is described. Lipase-catalyzed regioselective transesterification of acetate proceeded on C-4 of the d-lyxopyranoside. Subsequently, stereochemistry of liberated secondary alcohol was inverted by way of oxidation and reduction by IBX and NaBH(OAc)3 to give l-ribopyranoside. After deprotection, the furanose–pyranose isomeric mixture was converged to the target molecule, taking advantage of lipase-catalyzed preferential acetylation of primary alcohol on C-5.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 59, Issues 1–3, July 2009, Pages 197–200
نویسندگان
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