کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
70674 48841 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The lipase-catalyzed asymmetric C–C Michael addition
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
The lipase-catalyzed asymmetric C–C Michael addition
چکیده انگلیسی

The example of enzyme-catalyzed asymmetric C–C Michael addition was observed using Lipozyme TLIM (immobilized lipase from Thermomyces lanuginosus) in organic medium in the presence of water. This biocatalysis is applicable to the Michael additions of a wide range of 1,3-dicarbonyl compounds and cyclohexanone to aromatic and heteroaromatic nitroolefins and cyclohexenone. The enantioselectivities up to 83% ee and yields up to 90% were achieved. The enzyme can be reused for three cycles.

The example of enzyme-catalyzed asymmetric Michael addition was observed using Lipozyme TLIM (immobilized lipase from Thermomyces lanuginosus) in organic medium in the presence of water. This biocatalysis is applicable to the Michael additions of a wide range of 1,3-dicarbonyl compounds and cyclohexanone to aromatic and heteroaromatic nitroolefins and cyclohexenone. The enantioselectivities up to 83% ee and yields up to 90% were achieved. The enzyme can be reused for three cycles.Figure optionsDownload as PowerPoint slideResearch highlights▶ The enzyme-catalyzed asymmetric C–C Michael addition was observed. ▶ Lipozyme TLIM (immobilized lipase from Thermomyces lanuginosus) was used in DMSO/H2O. ▶ The enantioselectivities up to 83% ee and yields up to 90% were achieved. ▶ The enzyme can be reused for three cycles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 68, Issues 3–4, March 2011, Pages 240–244
نویسندگان
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