کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
70827 | 48848 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of novel glycoconjugates and evaluation as inhibitors against β-glucosidase from almond
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of novel glycoconjugates and evaluation as inhibitors against β-glucosidase from almond Synthesis of novel glycoconjugates and evaluation as inhibitors against β-glucosidase from almond](/preview/png/70827.png)
چکیده انگلیسی
Hydrolytic activity of glycosidases can be influenced by inhibitors of glycosidic nature. We have synthetized a serie of glycoconjugates consisting of galactose, glucosaminide or lactose 1-O-linked with allyl alcohol, pentenol or tetraethyleneglycol moieties. These compounds were found to be inhibitors of the hydrolase activity of the β-glucosidase from almond, with Ki in the range of 7.7–107 mM and presenting different types of inhibition. Based on the structure of the functionalized glycosides and the inhibition studies performed, we suggest that the nature of the carbohydrate is determinant in the inhibitory strength of these glycoconjugates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volumes 52–53, June 2008, Pages 153–157
Journal: Journal of Molecular Catalysis B: Enzymatic - Volumes 52–53, June 2008, Pages 153–157
نویسندگان
María Pérez, F. Javier Muñoz, Eva Muñoz, María Fernández, José Vicente Sinisterra, María J. Hernáiz,