کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
70852 48849 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solvent effects on the enantioselectivity of the thermophilic lipase QLM in the resolution of (R, S)-2-octanol and (R, S)-2-pentanol
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Solvent effects on the enantioselectivity of the thermophilic lipase QLM in the resolution of (R, S)-2-octanol and (R, S)-2-pentanol
چکیده انگلیسی

The thermophilic lipase QLM-catalyzed resolution of (R, S)-2-octanol and (R, S)-2-pentanol via transesterification was carried out in various organic solvents, and the solvent effects on the enzyme's enantioselectivity were investigated. A significant negative correlation between the enantiomeric ratio, E, and the size of the solvent molecules was observed. The highest E value, 21, was obtained in the small molecular-sized solvent dichloromethane when (R, S)-2-octanol was resolved with vinyl acetate as acyl donor. Thermodynamic analysis indicated that the difference in activation free energy between the two enantiomers was about 25.5% lower in dichloromethane than in the solvent-free system, and the change in the difference in activation entropy between the enantiomers was the main contributor to the changes in E values with the molecular size of solvents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 56, Issues 2–3, February 2009, Pages 146–150
نویسندگان
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