کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
70920 | 48854 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of enantioselectivity in lipase-catalyzed acylation of hydroxyalkylphosphine oxides
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of enantioselectivity in lipase-catalyzed acylation of hydroxyalkylphosphine oxides Evaluation of enantioselectivity in lipase-catalyzed acylation of hydroxyalkylphosphine oxides](/preview/png/70920.png)
چکیده انگلیسی
The lipase-catalyzed optical resolution of 2-, 3-, and 5-hydroxyalkyl phosphorus compounds 1 provided the corresponding optically pure diastereomers in good yields. (SP, R)- and (RP, S)-1 were acylated faster than (SP, S)- and (RP, R)-1. The stereoselectivity at the phosphorus atom changed with the flexibility of the active sites in the lipases. The stereoselectivity at the phosphorus atom was higher in the reaction of 1a than in the reaction of 1b,c. The reaction rate of É-hydroxyalkylphosphine oxide 1c was faster than that of 1a, although less enantioselectivity was observed at the phosphorus atom.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 55, Issues 3â4, November 2008, Pages 146-151
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 55, Issues 3â4, November 2008, Pages 146-151
نویسندگان
Kosei Shioji, Takafumi Ueyama, Nobuaki Ueda, Emiko Mutoh, Tsutomu Kurisaki, Hisanobu Wakita, Kentaro Okuma,