کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
70997 | 48860 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Naphthalene-dioxygenase-catalysed cis-dihydroxylation of azaarene derivatives: Part 1: 2-Pyridones and 2-quinolones
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The scope of the biotransformation of 2-pyridone- and 2-quinolone-derived compounds by recombinant whole-cells of E. coli JM109(DE3)(pDTG141) expressing the naphthalene-dioxygenase system from Pseudomonas sp. NCIB 9816-4 was explored, using a series of N- and C-substituted derivatives. Among them, only the N-methyl substituted compounds were good substrates for a regio- and stereoselective dihydroxylation reaction leading to cis-dihydroxydihydro pyridone derivatives, corresponding to the general pattern expected for this enzyme. In the absence of dihydroxylation reactions, N-dealkylations and monohydroxylations on external methyl groups were observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 50, Issues 2–4, 1 February 2008, Pages 53–60
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 50, Issues 2–4, 1 February 2008, Pages 53–60
نویسندگان
Claude Chopard, Robert Azerad, Thierry Prangé,