کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
71069 48867 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel selective biocatalytic deacetylation studies on dihydropyrimidinones
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Novel selective biocatalytic deacetylation studies on dihydropyrimidinones
چکیده انگلیسی

Five racemic ethyl 4-(3/4-acetoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylates have been synthesized by acetylation of corresponding hydroxy analogues, which in turn have been synthesized under microwave condition by multi-component Biginelli cyclocondensation of ethyl acetoacetate, urea and the corresponding hydroxybenzaldehydes in the presence of ferric chloride. These dihydropyrimidinones have been subjected to biocatalytic resolution using acetoxyl group on the phenyl ring as remote handle; Novozyme®-435, an immobilized lipase from Candida antarctica in THF:DIPE has been found to catalyze the deacetylation reactions in an enantioselective fashion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 40, Issues 3–4, 1 June 2006, Pages 93–100
نویسندگان
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