کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
71135 | 48875 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Convenient synthesis of β-galactosyl nucleosides using the marine β-galactosidase from Aplysia fasciata
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Convenient synthesis of β-galactosyl nucleosides using the marine β-galactosidase from Aplysia fasciata Convenient synthesis of β-galactosyl nucleosides using the marine β-galactosidase from Aplysia fasciata](/preview/png/71135.png)
چکیده انگلیسی
A convenient synthesis of β-galactosyl derivatives of antiviral and anticancer nucleosides, which utilizes the purified β-galactosidase activity from the hapatopancreas of Aplysia fasciata, is reported. All reactions were extremely stereo- and regioselective, since only anomerically pure 5′-O-β-galactosyl conjugates were formed. 5′-O-β-Galactosyl-5-fluorouridine was synthesized with a 60% yield and 5′-O-β-galactosyl-3′-azido-3′-deoxythymidine, the derivative of the anti-HIV drug, was obtained in 43% yield.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 47, Issues 1–2, 1 June 2007, Pages 28–32
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 47, Issues 1–2, 1 June 2007, Pages 28–32
نویسندگان
Giuseppina Andreotti, Antonio Trincone, Assunta Giordano,