Facile preparation of UiO-66 nanoparticles with tunable sizes in a continuous flow microreactor and its application in drug delivery

• Continuous flow microreactor was used to prepare UiO-66 nanoparticles.
• UiO-66 nanoparticles have been facilely prepared.
• The particle size can be well tuned by controlling the residence time.
• Drug delivery behavior of 5-fluorouracil was studied.

In this paper, UiO-66 nanoparticles have been facilely prepared in a continuous flow microreactor, in which the particle size can be tuned from hundreds to dozens of nanometers by controlling of the residence time. All the products have been completely characterized by FT-IR, PXRD, N2 sorption, SEM and TEM. Furthermore, NH2-functionalized nano-UiO-66 particles have also been prepared and the drug delivery behavior for 5-fluorouracil (5-Fu) was studied in PBS solution.

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