کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7232329 | 1470962 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amplified electrochemical sensing of lead ion based on DNA-mediated self-assembly-catalyzed polymerization
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Lead ion (Pb2+, a heavy metal ion existed every aspect of life) is one of the most important hazards for environment and human health. Herein we design an in-situ amplified electronic monitoring system for sensitive determination of Pb2+ on Pb2+-specific DNAzyme-modified sensing interface. The assay consists of target-triggered cleavage of Pb2+-specific DNAzyme, initiator strand-induced DNA hybridization chain reaction, formation of hemin/G-quadruplex -based DNAzyme and its automatically catalyzed polymerization of aniline monomer along the double-stranded DNA. Experimental results indicated that the catalytic currents of the as-produced polyaniline were linearly dependent on target Pb2+ concentrations from 0.05 to 50Â nM with a detection limit (LOD) of 32Â pM. Such a synergistic effect of hybridization chain reaction with DNAzyme-catalyzed polymerization provided a universal platform for sensitive screening of target Pb2+, thereby holding great promise for application in practice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 69, 15 July 2015, Pages 230-234
Journal: Biosensors and Bioelectronics - Volume 69, 15 July 2015, Pages 230-234
نویسندگان
Bing Zhang, Jinfeng Chen, Bingqian Liu, Dianping Tang,