کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7232509 1470964 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optical waveguide sensor based on silica nanotube arrays for label-free biosensing
ترجمه فارسی عنوان
سنسور موج نوری بر اساس آرایشهای نانولوله سیلیکا برای بیوسنزینگ بدون برچسب
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Label-free biosensing based on optical waveguide spectroscopy of silica nanotube (SNT) arrays is realized with high sensitivity. The SNT arrays fabricated using a porous anodic alumina (PAA) template assisted by surface sol-gel (SSG) method showed a high value of 552 reciprocal refractive index unit as the sensing figure of merit by exchanging the sensing environment with water and ethanol. A standard biotin-streptavidin affinity model was tested using the SNT arrays which support a TM1 mode and the fundamental response of the system was investigated. Results show that the response of the SNT arrays for adsorption of streptavidin is higher than the one using substrate without removing the PAA template due to the larger surface area and the stronger electromagnetic field. The limit of detection (LOD) of the SNT arrays for detection of streptavidin was estimated as 93 pM, with the detection time of 40 min. Additionally, the Fresnel calculations suggested higher potential sensitivity of the current system compared to that of the conventional SPR sensors. Thus, the SNT arrays may be used as a versatile platform for high-sensitive label-free optical biosensing due to the high performance and the large potential of the surface functionality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 67, 15 May 2015, Pages 230-236
نویسندگان
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