کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7233673 | 1470977 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies IGZO thin film transistor biosensors functionalized with ZnO nanorods and antibodies](/preview/png/7233673.png)
چکیده انگلیسی
We demonstrate a biosensor structure consisting of an IGZO (Indium-Gallium-Zinc-Oxide) TFT (thin film transistor) and an extended sensing pad. The TFT acts as the sensing and readout device, while the sensing pad ensures the isolation of biological solution from the transistor channel layer, and meanwhile increases the sensing area. The biosensor is functionalized by first applying ZnO nanorods to increase the surface area for attracting electrical charges of EGFR (epidermal growth factor receptor) antibodies. The device is able to selectively detect 36.2Â fM of EGFR in the total protein solution of 0.1Â ng/ml extracted from squamous cell carcinoma (SCC). Furthermore, the conjugation duration of the functionalized device with EGFR can be limited to 3Â min, implying that the biosensor has the advantage for real-time detection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 54, 15 April 2014, Pages 306-310
Journal: Biosensors and Bioelectronics - Volume 54, 15 April 2014, Pages 306-310
نویسندگان
Yi-Chun Shen, Chun-Hsu Yang, Shu-Wen Chen, Shou-Hao Wu, Tsung-Lin Yang, Jian-Jang Huang,