A label-free electrochemical assay for methyltransferase activity detection based on the controllable assembly of single wall carbon nanotubes

► We develop an electrochemical strategy for assay MTase activity and inhibition. ► The electrochemical assay is based on single wall carbon nanotubes. ► Signal transduction and amplification of single wall carbon nanotubes. ► It is a label-free, sensitive route for the detection of MTase activity. ► The screening of the inhibitors of MTase can be achieved based on the assay.