Functionalized ensembles of nanoelectrodes as affinity biosensors for DNA hybridization detection

► Highly sensitive electrochemical DNA sensors prepared on nanoelectrode ensembles. ► The probe is immobilized on the polycarbonate surrounding the nanoelectrodes. ► Enzyme label bound to the target gives electrocatalytic amplification. ► Biorecognition and transduction are integrated but separated on a nanometer scale.